I had the same issue where after I click "New Game" and confirm it, about 10-15 seconds into the load screen my game would crash instantly. No idea how to fix it. I've tried changing the sound quality to every possible frequency and each one resulted in a crash. I have no idea what else to do now. EDIT I found a fix that worked for me. I believe it had to do with the V-sync. Although the guide says to script it in, my Intel graphics card also has a feature to disable Vsync. I had to script it into the .ini file as well as tell my graphics card to disable Vsync.