I don't know too much of the ram because I have never run 4x2GB. But I believe it will be difficult to run 4 sticks together at the 1066 speed with my called back memory of trying to run 4 sticks of Gskill LE TCCD ram (4x512) at 600 MHz long time ago.
I think most of the high end boards can support 500+ FSB. However, for the new quad core from intel Q9450 / X3350 series, there are still very few people able to run at 500 FSB with the cpu. Cpu FSB wall may be the barrier if you are intend to oc it to 4Ghz